Tao Shen
School of Pharmaceutical Sciences
Shandong University
No. 44 West Wen-Hua Road
Jinan 250012, P. R. China
Tel: +86-531-88382028
Cell: +86-13793152881
E-mail: shentao@sdu.edu.cn
shen_email@sina.com
Education and Professional Experience
Lecturer in pharmacognosy (July 2009 - )
School of Pharmaceutical Sciences, Shandong University, Jinan, P. R. China
Postdoc in Pharmacology and Toxicology (Jun 2012 - Jun 2013)
College of Pharmacy, the University of Arizona, Tucson, AZ, United States
Ph.D. in Medicinal Chemistry (Aug 2004 - July 2009)
School of Pharmaceutical Sciences, Shandong University, Jinan, P. R. China
B.S. in Pharmacy (Aug 2000- July 2004)
School of Pharmaceutical Sciences, Shandong University, Jinan, P. R. China
Research Expertise and Interests:
Extraction, isolation, characterization and mechanism of bioactive metabolites from natural sources
Spectroscopic analyses and structural identification of natural products
New drug research and development from traditional Chinese medicines
Quantification of constituents and quality control of traditional Chinese medicines (herbs)
Sponsored Researches:
Discovery of anti-prostate secondary metabolites from Commiphora species and their mechanism. Supported by the National Natural Science Foundation of China (No. 81001376), Jan 2011 – Dec 2013, Fund: 200,000 RBM.
New drug research and development of an anti-diabetic traditional medicine. Supported by the Science and Technological Administration of Shandong Province (No. 2011GSF11909), Jan 2011 – Dec 2012, Fund: 220,000 RBM.
solation and elucidation of anti-tumor constituents from myrrh. Supported by Shandong University, Jan 2010 – Dec 2011, Fund: 80,000 RBM.
Anti-prostate substances and their mechanism. Supported by Postdoctoral Innovation Foundation of Shandong Province, Jan 2011 – Dec 2012, Fund: 50,000 RBM
Modification, SAR and mechanism of anti-tumor triterpenoids from myrrh based on AR signaling pathway and rhamnose lectin receptors. Supported by China Postdoctoral Science Foundation, Jul 2011 – Dec 2012, Fund: 100,000 RBM
Complete List of Publications:
Peer reviewed publications:
Shen T, Zhang L, Wang YY, Fan PH, Wang XN, Lin ZM, Lou HX. Steroids from Commiphora mukul display antiproliferative effect against human prostate cancer PC3 cells via induction of apoptosis. Bioorganic & Medicinal Chemistry Letter, 2012, 22, 4801–4806.
Shen T, Li GH, Wang XN, Lou HX. The genus Commiphora: A review of its traditional uses, phytochemistry and pharmacology. Journal of Ethnopharmacology, 2012, 142, 319–330.
Shen T, Wang XN, Lou HX. Natural stilbenes: an overview. Natural Product Reports, 2009, 26, 916–935.
Shen T, Wan WZ, Yuan HQ, Kong F., Guo HF, Fan PH, Lou HX. Secondary metabolites from Commiphora opobalsamum and their antiproliferative effect on human prostate cancer cells. Phytochemistry, 2007, 68, 1331–1337.
Shen T, Yuan HQ, Wan WZ, Wang XL, Wang XN, Ji M, Lou HX. Cycloartane-type triterpenoids from the resinous exudates of Commiphora opobalsamum. Journal of Natural Products, 2008, 71, 81–86.
Shen T, Wan WZ, Wang XN, Sun LM, Yuan HQ, Wang XL, Ji M, Lou HX. Sesquiterpenoids from the resinous exudates of Commiphora opobalsamum (Burseraceae). Helvetica Chimica Acta, 2008, 91, 881– 887.
Shen T, Lou HX. Bioactive constituents of myrrh and frankincense, two simultaneously prescribed gum resins in Chinese traditional medicine. Chemistry & Biodiversity, 2008, 5, 540–553.
Shen T, Wan WZ, Wang XN, Yuan HQ, Ji M, Lou HX. A triterpenoid and sesquiterpenoids from the resinous exudates of Commiphora myrrha. Helvetica Chimica Acta, 2009, 92, 645–652.
Shen T, Xiang L, Ren D-M, Wang S-Q, Yang M-R, Lou H-X. Seasonal variation, microscopic and chromatographic analysis of leaves in Malus hupehensis: a protocol for its quality control. Chinese Herbal Medicines, 2013, 5, 145–150.
Zhong QQ, Zhou HL, Shen T*. Biotransformation of cycloartane-type triterpenoid from myrrh. Journal of Chinese Medicinal Materials, 2012, 35, 1098–1101. (in Chinese)
Shen T, Gao YH, Lou HX. Determination of ginkgolides and bilobalide in Ginkgo biloba L. leaves collected in various months by LC-MS/MS. Chinese Pharmaceutical Journal, 2008, 43, 380–383. (in Chinese)
Shen T, Lou HX. Chemical constituents from resin of Commiphora species and their biological activities. Natural Product Research and Development, 2008, 20, 360–366. (in Chinese)
Book Chapters:
1. Shen T, Xie CF, Lou HX. (2013) 63 stilbenoid. In Ramawat K. G., Merillon J-M. (eds.) Handbook of Natural Products, Springer Heidelberg, New York, Dordrecht, London.
2. Shen T, Lou HX. Chemical constituents from Bryophytes: an overview, In Chemistry and Biology of Bryophytes; Lou HX. Eds.; Beijing Science and Technology Press: Beijing, 2006; pp 280-347. (in Chinese)
3. Lou HX, Shen T. Tropane alkaloids; Emetine alkaloids. In Alkaloid Chemistry; Wang FP Eds.; Chemical Industry Press: Beijing, 2008; pp 30–52 and 240–252. (in Chinese)
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