RM 403, New Research Building
School of Pharmaceutical Sciences Shandong University, Jinan 250012, China
Tel/Fax: 86-531-88382162
Email: leiliu@sdu.edu.cn |
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Present Position:
“Qilu Young Scholar” Professor, Supervisor of PhD Candidates
Education Background:
2006.09-2011.03 Ph.D, Organic Chemistry, University of Pittsburgh, Pittsburgh, US
Department of Chemistry Advisor: Paul E. Floreancig
2003.09-2006.07 M.S., Biochemistry and Molecular Biology, Lanzhou University
School of Life Science Advisor: Rui Wang
1999.09-2003.07 B.S., Biological Science, Lanzhou University, China
School of Life Science Advisor: Rui Wang
Professional Experience:
2012.06-present Professor, School of Pharmaceutical Sciences, Shandong University
2011.03-2012.05 Post-doctoral Fellow, Organic Chemistry, Department of Chemistry and Chemical Biology, Harvard University, Boston, MA, USA
Honors and Awards:
The Shandong Science Fund for Distinguished Young Scholars, 2014
New Century Excellent Talents in University, 2013
Qilu Young Scholar, Shandong University, 2012
Chinese Government Award for Outstanding Self-Financed Students Abroad, 2011 Organic Chemistry Graduate Research Symposium Awards, 2010
Chinese Academy of Sciences Scholarships, 2005
Teaching Courses:
《Advanced Organic Chemistry》、《Name Reactions》
Research Interests:
(1) Synthetic Methodology Development
(2) Natural Product Synthesis and SAR Studies
(3) Medicinal Chemistry
Research Grant Support:
Currently Active:
The Shandong Science Fund for Distinguished Young Scholars
The National Natural Science Foundation of China (Youth & Mianshang)
“Qilu Young Scholar” Startup Foundation
Young Scientist Foundation Grant of Shandong Province
New Century Excellent Talents in University
The Fundamental Research Funds of Shandong University
Publication List
Independent Work at SDU
2015
10. Liu, X.; Meng, Z.; Li, C.; Lou, H.; Liu, L.* Organocatalytic Enantioselective Oxidative C-H Alkenylation and Arylation of N-Carbamoyl Tetrahydropyridines and Tetrahydro-β-Carbolines. Angew. Chem. Int. Ed. 2015, DOI: 10.1002/anie.201500703R1.
2014
9. Chen, W.; Xie, Z.; Zheng, H.; Lou, H.*; Liu, L.* Structurally Diverse α-Substituted Benzopyran Synthesis through A Practical Metal-Free C(sp3)-H Functionalization. Org. Lett. 2014, 16, 5988.
8. Sun, S.; Yang, J.; Li, F.; Lv, Z.; Li, W.*; Lou, H.*; Liu, L.* Seven- and Eight-Membered Heterocyclic Biaryl Synthesis through A Metal-Free Oxidative Coupling Reaction. Tetrahedron Lett. 2014, 55, 6899.
7. Wan, M.; Meng, Z.; Lou, H.; Liu, L.* Practical and Highly Selective C-H Functionalization of Structurally Diverse Ethers. Angew. Chem. Int. Ed. 2014, 53, 13845.
·Selected as “hot paper” by Angew Chem.
6. Yang, J.; Sun, S.; Zeng, Z.; Zheng, H.; Lou, H.; Liu, L.* An economic and Environmentally Friendly Oxidative Biaryl Coupling Promoted by Activated MnO2. Org. Biomol. Chem. 2014, 12, 7774.
5. Pan, X. H.; Hu, Q. W.; Chen, W. F.; Liu, X. G.; Sun, B.; Huang, Z. L.; Zeng, Z. Y.; Wang, L. G.; Zhao, D.; Ji, M.; Liu, L.*; Lou, H. X.* Copper(II) Catalyzed Cross-Dehydrogenative Coupling of Cyclic Benzylic Ethers with Simple Carbonyl Compounds by Na2S2O8. Tetrahedron 2014, 70, 3447.
4. Chen, W. F.; Zheng, H. B.; Pan, X. H.; Xie, Z. Y.; Zan, X.; Sun, B.; Liu, L.*; Lou, H. X.* A Metal-Free Cross-Dehydrogenative Coupling of N-Carbamoyl Tetrahydroispquinoline by Sodium Persulfate. Tetrahedron Lett. 2014, 55, 2879.
3. Xie, Z. Y.; Liu, L.*; Chen, W. F.; Zheng, H. B.; Xu, Q. Q.; Yuan, H. Q.; Lou, H. X.* Practical Metal-Free C(sp3)-H Functionalization: Construction of Structurally Diverse a-Substituted N-Benzyl and N-Allyl Carbamates. Angew. Chem. Int. Ed. 2014, 53, 3904.
·Highlighted by Chinese J Org Chem
2. Meng, Z. L.; Sun, S. T.; Yuan, H. Q.; Lou, H. X.*; Liu, L.* Catalytic Enantioselective Oxidative Cross-Coupling of Benzylic Ethers with Aldehydes. Angew. Chem. Int. Ed. 2014, 53, 543.
·selected as “Hot Paper” by Angew Chem.
·Highlight by Synfact, 2014, 341.
2013
1. Liu, X. G.; Sun, B.; Xie, Z. Y.; Qin, X. J.; Liu, L.*; Lou, H. X.* Manganese dioxide-Methanesulfonic Acid Promoted Direct Dehydrogenative Alkylation of sp3 C–H Bonds Adjacent to A Heteroatom. J. Org. Chem. 2013, 78, 3104.
Postdoc at Harvard （2011-2012）
21. Liu, L.; Henderson, J. A.; Yamamoto, A.; Brémond, P.; Kishi, Y. Synthesis of Alcohols from m-Fluorophenylsulfones and Dialkylboranes: Application to the C14-C35 Building Block of E7389. Org. Lett. 2012, 14, 2262.
PhD at Pitt（2006-2011）
20. Liu, L.; Floreancig, P. E. Stereoselective Synthesis of Tertiary Ethers through Geometrical Control of Highly Substituted Oxocarbenium Ions. Angew. Chem. Int. Ed. 2010, 49, 5894. (Highlighted in SynFacts 2010, 1152 and Synstory 2010, A101)
19. Liu, L.; Floreancig, P. E. Structurally and Stereochemically Diverse Tetrahydropyran Synthesis through Oxidative Carbon–Hydrogen Bond Activation. Angew. Chem. Int. Ed. 2010, 49, 3069. (Selected as “Hot Paper” in Angew. Chem. Int. Ed.)
18. Liu, L.; Floreancig, P. E. Stereoselective Heterocycles Synthesis through Oxidative Carbon–Hydrogen Bond Activation. Curr. Opin. Drug. Discov. Devel. 2010, 13, 733.
17. Liu, L.; Floreancig, P. E. DDQ-Catalyzed Reactions Employing MnO2 as A Stoichiometric Oxidant. Org. Lett. 2010, 12, 4686.
16. Liu, L.; Floreancig, P. E. Cyclization Reactions through DDQ-Mediated Vinyl Oxazolidinone Oxidation. Org. Lett. 2009, 11, 3152. (Highlighted in SynFacts 2009, 998)
15. Tu, W.; Liu, L.; Floreancig, P. E. Diastereoselective Tetrahydropyrone Synthesis through Transition-Metal-Free Oxidative Carbon–Hydrogen Bond Activation. Angew. Chem. Int. Ed. 2008, 47, 4184.
14. Zaware, N.; LaPorte, M. G.; Fraid, R.; Liu, L.; Wipf, P.; Floreancig, P. E. Diversity-Oriented Synthesis of a Library of Substituted Tetrahydropyrones using Oxidative Carbon–Hydrogen Bond Activation and Click Chemistry. Molecules 2011, 16, 3648.
Ms at LZU（2003-2006）
13. Liu, L.; Wang, R.; Kang, Y.-F.; Cai, H.-Q.; Chen, C. Highly Enantioselective Addition of Phenylacetylene to Ketones Catalyzed by Bis(hydroxycamphorsulfonamide)–Copper(II) Complex. Synlett. 2006, 8, 1245.
12. Liu, L.; Wang, R.; Kang, Y.-F.; Chen, C.; Xu, Z.-Q.; Zhou, Y.-F.; Ni, M.; Cai, H.-Q.; Gong, M.-Z. Highly Enantioselective Phenylacetylene Addition to Aromatic Ketones Catalyzed by Cinchona Alkaloid-Aluminum Complexes. J. Org. Chem. 2005, 70, 1084.
11. Liu, L.; Kang, Y.-F.; Wang, R.; Zhou, Y.-F.; Chen, C.; Ni, M.; Gong, M.-Z. Enantioselective Alkynylation of Aromatic Ketones Promoted by (S)-Phenylalanine-derived β-Amino Alcohol. Tetrahedron: Asymmetry 2004, 15, 3757.
10. Kang, Y.-F.; Liu, L.; Wang, R.; Zhou, Y.-F.; Yan, W.-J. Enantioselective Alkynylation of Aromatic Ketones Catalyzed by New Chiral Oxazolidine Ligands. Adv. Synth. Catal. 2005, 347, 243.
9. Kang, Y.-F.; Liu, L.; Wang, R.; Yan, W.-J.; Zhou, Y.-F. The Use of Bifunctional Catalyst Systems in the Asymmetric Addition of Alkynylzinc to Aldehydes. Tetrahedron: Asymmetry 2004, 15, 3155.
8. Kang, Y.-F.; Liu, L.; Wang, R.; Ni, M.; Han, Z.-J. Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Catalyzed by New Chiral Oxazolidine Ligand. Synth. Commun. 2005, 35, 1819.
7. Kang, Y.-F.; Wang, R.; Liu, L.; Da, C.-S.; Yan, W.-J.; Xu, Z.-Q. Enantioselective Alkynylation of Aromatic Aldehydes Catalyzed by New Chiral Oxazolidine Ligands. Tetrahedron Lett. 2005, 46, 863.
6. Chen, C.; Hong, L.; Xu, Z.-Q.; Liu, L.; Wang, R. Low Ligand Loading, Highly Enantioselective Addition of Phenylacetylene to Aromatic Ketones Catalyzed by Schiff-Base Amino Alcohols. Org. Lett. 2006, 8, 2277.
5. Cai, H.-Q.; Chen, C.; Liu, L.; Ni, J.-M.; Wang, R. A New Type of Ligand Derived from N-Terminal Protected Dipeptides in Enantioselective Addition of Phenylacetylene to Aromatic Ketones at Room Temperature. J. Mol. Catal. A: Chem. 2006, 253, 86.
4. Han, Z.-J.; Wang, R.; Zhou, Y.-F.; Liu, L. Simple Derivatives of Natural Amino Acids as Chiral Ligands in the Catalytic Asymmetric Addition of Phenylacetylene to Aldehydes. Eur. J. Org. Chem. 2005, 934.
3. Ni, M.; Wang, R.; Han, Z.-J.; Mao, B.; Da, C.-S.; Liu, L.; Chen, C. Synthesis of New C2-Symmetrical Bissulfonamide Ligands and Application in the Enantioselective Addition of Alkynylzinc to Aldehydes and Ketones. Adv. Synth. Catal. 2005, 347, 1659.
2. Zhou, Y.-F.; Wang, R; Xu, Z.-Q.; Yan, W.-J.; Liu, L.; Kang, Y.-F.; Han, Z.-J. Highly Enantioselective Phenylacetylene Additions to Ketones Catalyzed by (S)-BINOL-Ti Complex. Org. Lett. 2004, 6, 4147.
1. Zhou, Y.-F.; Wang, R; Xu, Z.-Q.; Yan, W.-J.; Liu, L.; Gao, Y.-F.; Da, C.-S. Boc-L-proline as A New Chiral Ligand for Enantioselective Phenylacetylene Addition to Aromatic Aldehydes. Tetrahedron: Asymmetry 2004, 15, 589.
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